Pyromaker: Online Application to Identify Gene Mutations

Johns Hopkins researchers have developed an easy-to-use online computer software application that can identify meaningful gene mutations faster and at less cost than other methods currently available. The software generates simulated pyrograms, which are readouts from a gene sequencing technique known as pyrosequencing. “Pyromaker,” is available free-of-charge. A related tutorial will be posted soon.

Pyromaker’s value is in rapidly sorting through each of several simulated pyrograms, until there is a clear match with the actual tumor pyrogram. This enables researchers to do in minutes, essentially at no cost, what otherwise would take days of further, expensive tests.

James R. Eshleman, M.D., Ph.D., a professor in the departments of Pathology and Oncology at Johns Hopkins, led the project. The software based approach in Pyromaker was written by Dr. Matthew T. Olson, and validated by Dr. Guoli Chen, both residents in the Department of Pathology. Their efforts were supported by those of a team of other researchers at Johns Hopkins.

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• Related Solutions

• Category: Service Line Management Solutions

• Source: Johns Hopkins Medicine

• Patient Care Process: Pre-care and Preventive care processes

• Tags: Software, Sequencing, Sequence, Oncology, Gene Mutations, Cancer Mutations, Cancer

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